منابع مشابه
Malaria vaccine boost
For decades detailed molecular biology about malaria has been accrued: but, throughout this time, the most effective measures in regions where the disease is endemic have continued to rely on the chemical and physical methods of insecticides and bednets, with drugs available to people travelling to these regions. So the latest study to test a new malaria vaccine developed by GlaxoSmithKline (GS...
متن کاملPrime-boost strategies for malaria vaccine development.
Malaria is an intracellular pathogen, for which an effective vaccine is likely to require induction of cell-mediated immunity. Immunisation approaches that stimulate strong and persistent levels of effector T-cells are being sought by many researchers. DNA vaccines, recombinant protein and viral vectors were amongst the vaccine delivery systems that appeared promising for the generation of cell...
متن کاملMalaria battle boost
Microsoft founder, Bill Gates, pledged more than $160 million from his charitable foundation to help develop vaccines for malaria as part of a package of funds totalling $3 billion revealed at a meeting at the UN to assess progress in the Millennium Development Goals to halve global poverty by 2015. Gates said that his funds would be for the PATH Malaria Vaccine Initiative (MVI), in conjunction...
متن کاملMultistage multiantigen heterologous prime boost vaccine for Plasmodium knowlesi malaria provides partial protection in rhesus macaques.
A nonhuman primate model for malaria vaccine development allowing reliable, stringent sporozoite challenge and evaluation of both cellular and antibody responses is needed. We therefore constructed a multicomponent, multistage DNA vaccine for the simian malaria species Plasmodium knowlesi including two preerythrocytic-stage antigens, the circumsporozoite protein (PkCSP) and sporozoite surface p...
متن کاملEvaluation of a prime-boost vaccine schedule with distinct adenovirus vectors against malaria in rhesus monkeys.
A vaccine that elicits both specific antibodies and IFN-gamma-producing T cells is required to protect against pre-erythrocytic malaria. Among the most promising approaches to induce such complex immunity are heterologous prime-boost vaccination regimens, in particular ones containing live viral vector. We have demonstrated previously that adenovectors serotype 35 (Ads35) encoding the circumspo...
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ژورنال
عنوان ژورنال: Current Biology
سال: 2007
ISSN: 0960-9822
DOI: 10.1016/j.cub.2007.11.010